The Web Server Gateway Interface (WSGI) is a standard interface between web server software and web applications written in Python. Having a standard interface makes it easy to use an application that supports WSGI with a number of different web servers.
Only authors of web servers and programming frameworks need to know every detail and corner case of the WSGI design. You don't need to understand every detail of WSGI just to install a WSGI application or to write a web application using an existing framework.
wsgiref is a reference implementation of the WSGI specification that can be used to add WSGI support to a web server or framework. It provides utilities for manipulating WSGI environment variables and response headers, base classes for implementing WSGI servers, a demo HTTP server that serves WSGI applications, and a validation tool that checks WSGI servers and applications for conformance to the WSGI specification (PEP 333).